Ventral Induction

Neurodevelopmental period when face and brain develop out of superior end of neural tube.

Ventral Induction Defects

• Holoprosencephaly: failure of brain cleavage 
  • alobar form: no cleavage at all resulting distinct cerebral hemispheres; no corpus 
  • semi lobar form: some cleavage and developmental of right and left hemispheres incomplete; no corpus callosum 
  • lobar form: least severe; brain looks normal but, abnormal connections between hemispheres